Which of the following is NOT a manifestation of Cushing's Disease?

Cushing's Disease is characterized by excessive cortisol production, which can lead to a variety of specific symptoms and physical changes. One of the hallmark manifestations of this condition is an increase in weight due to fat redistribution, especially around the abdomen and face, resulting in a “moon face” appearance. This weight gain is contrary to the symptom of weight loss, which is generally not associated with Cushing's Disease.

In addition to delayed wound healing, hypertension, and fatigue, weight gain is a common occurrence as cortisol influences metabolism and fat storage. Therefore, choosing weight loss as a manifestation of Cushing's Disease highlights an important aspect of the condition, where individuals typically experience weight gain instead.